Human IFNa/bR2 (Interferon Alpha/Beta Receptor 2) Sandwich ELISA Kit Ready-To-Use (STJE0016046) STJE0016046 上海玉博生物科技有限公司

Human IFNa/bR2 (Interferon Alpha/Beta Receptor 2) Sandwich ELISA Kit Ready-To-Use (STJE0016046)

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产品名称：Human IFNa/bR2 (Interferon Alpha/Beta Receptor 2) Sandwich ELISA Kit Ready-To-Use (STJE0016046)
产品型号：STJE0016046
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human IFNa/bR2 (Interferon Alpha/Beta Receptor 2) Sandwich ELISA Kit Ready-To-Use (STJE0016046)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.235ng/mL
Detection Limit:	0.625-40ng/mL
Short Description:	This IFNa/bR2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	IFNAR2
Gene ID:	3455
Uniprot ID:	INAR2_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, urine or other biological fluids.

Tissue Specificity	Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
Post Translational Modifications	Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types. Glycosylated.
Function	Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Isoform 3: Potent inhibitor of type I IFN receptor activity.
Protein Name	Interferon Alpha/Beta Receptor 2 Ifn-R-2 Ifn-Alpha Binding Protein Ifn-Alpha/Beta Receptor 2 Interferon Alpha Binding Protein Type I Interferon Receptor 2
Database Links	Reactome: R-HSA-909733 P48551-2 Reactome: R-HSA-912694 P48551-2 Reactome: R-HSA-9679191 P48551-2 Reactome: R-HSA-9705671 P48551-2
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Cell Membrane Isoform 3: Secreted
Alternative ELISA Names	Interferon Alpha/Beta Receptor 2 ELISA kit Ifn-R-2 ELISA kit Ifn-Alpha Binding Protein ELISA kit Ifn-Alpha/Beta Receptor 2 ELISA kit Interferon Alpha Binding Protein ELISA kit Type I Interferon Receptor 2 ELISA kit IFNAR2 ELISA kit IFNABR ELISA kit IFNARB ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human IFNa/bR2 (Interferon Alpha/Beta Receptor 2) Sandwich ELISA Kit Ready-To-Use (STJE0016046)