Anti-Caspase-9 antibody (139-416) [S7MR] (STJ11102737) STJ11102737 上海玉博生物科技有限公司

Anti-Caspase-9 antibody (139-416) [S7MR] (STJ11102737)

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产品名称：Anti-Caspase-9 antibody (139-416) [S7MR] (STJ11102737)
产品型号：STJ11102737
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Caspase-9 antibody (139-416) [S7MR] (STJ11102737)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-Caspase-9 (139-416) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Monoclonal
Clone ID:	S7MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:100
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CASP9
Gene ID:	842
Uniprot ID:	CASP9_HUMAN
Immunogen Region:	139-416
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 139-416 of Caspase-9 (NP_001220.2).
Immunogen Sequence:	VGALESLRGNADLAYILSME PCGHCLIINNVNFCRESGLR TRTGSNIDCEKLRRRFSSLH FMVEVKGDLTAKKMVLALLE LAQQDHGALDCCVVVILSHG CQASHLQFPGAVYGTDGCPV SVEKIVNIFNGTSCPSLGGK PKLFFIQACGGEQKDHGFEV ASTSPEDESPGSNPEPDATP FQEGLRTFDQLDAISSLPTP SDIFVSYSTFPGFVSWRDPK SGSWYVETLDDIFEQWAHS

Tissue Specificity	Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Post Translational Modifications	Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events. Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing and subsequent caspase-3 activation. Phosphorylation on Tyr-153 by ABL1/c-Abl.occurs in the response of cells to DNA damage. (Microbial infection) ADP-riboxanation by C.violaceum CopC blocks CASP9 processing, preventing CASP9 activation and ability to mediate intrinsic apoptosis.
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2: Lacks activity is an dominant-negative inhibitor of caspase-9.
Protein Name	Caspase-9 Casp-9 Apoptotic Protease Mch-6 Apoptotic Protease-Activating Factor 3 Apaf-3 Ice-Like Apoptotic Protease 6 Ice-Lap6 Cleaved Into - Caspase-9 Subunit P35 - Caspase-9 Subunit P10
Database Links	Reactome: R-HSA-111458 Reactome: R-HSA-111459 Reactome: R-HSA-111463 Reactome: R-HSA-111464 Reactome: R-HSA-168638 Reactome: R-HSA-198323 Reactome: R-HSA-418889 Reactome: R-HSA-5674400 Reactome: R-HSA-9627069
Alternative Antibody Names	Anti-Caspase-9 antibody Anti-Casp-9 antibody Anti-Apoptotic Protease Mch-6 antibody Anti-Apoptotic Protease-Activating Factor 3 antibody Anti-Apaf-3 antibody Anti-Ice-Like Apoptotic Protease 6 antibody Anti-Ice-Lap6 Cleaved Into - Caspase-9 Subunit P35 - Caspase-9 Subunit P10 antibody Anti-CASP9 antibody Anti-MCH6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Caspase-9 antibody (139-416) [S7MR] (STJ11102737)