Anti-CASQ1 antibody (322-372 aa) (STJ194071) STJ194071 上海玉博生物科技有限公司

Anti-CASQ1 antibody (322-372 aa) (STJ194071)

简单介绍

Anti-CASQ1 antibody (322-372 aa) (STJ194071)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Calsequestrin-1 (322-372 aa) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CASQ1
Gene ID:	844
Uniprot ID:	CASQ1_HUMAN
Immunogen Region:	322-372 aa
Specificity:	This antibody detects endogenous levels of CASQ1 at Human/Mouse/Rat
Immunogen:	Synthesized peptide derived from the human CASQ1 at the amino acid range 322-372

Post Translational Modifications	N-glycosylated.
Function	Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1.this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity.
Protein Name	Calsequestrin-1 Calmitine Calsequestrin - Skeletal Muscle Isoform
Database Links	Reactome: R-HSA-2672351 Reactome: R-HSA-5578775
Cellular Localisation	Endoplasmic Reticulum Sarcoplasmic Reticulum Sarcoplasmic Reticulum Lumen Sarcoplasmic Reticulum Membrane Peripheral Membrane Protein Lumenal Side Mitochondrion Matrix This Isoform Of Calsequestrin Occurs In The Sarcoplasmic Reticulum's Terminal Cisternae Luminal Spaces Of Fast Skeletal Muscle Cells Preferentially Forms Linear And Round Aggregates In The Endoplasmic Reticulum (Er) Of Resting Cells In A Minority Of Cells Homogeneously Detected In The Er Lumen Colocalizes With Stim1 At Endoplasmic Reticulum In Response To A Depletion Of Intracellular Calcium
Alternative Antibody Names	Anti-Calsequestrin-1 antibody Anti-Calmitine antibody Anti-Calsequestrin - Skeletal Muscle Isoform antibody Anti-CASQ1 antibody Anti-CASQ antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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