Anti-CASR antibody (47-69) {FITC} (STJ500368) STJ500368-100 上海玉博生物科技有限公司

Anti-CASR antibody (47-69) {FITC} (STJ500368)

简单介绍

Anti-CASR antibody (47-69) {FITC} (STJ500368)

产品描述

Host:	Rabbit
Applications:	ELISA/IHC/IP/WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CASR (47-69) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.7 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:150 IHC: 1:50-1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	CASR
Gene ID:	846
Uniprot ID:	CASR_HUMAN
Immunogen Region:	47-69
Immunogen:	Synthetic peptide corresponding to amino acids 47-69 on human CASR gene.

Tissue Specificity	Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.
Post Translational Modifications	N-glycosylated. Ubiquitinated by RNF19A.which induces proteasomal degradation.
Function	G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation.
Protein Name	Extracellular Calcium-Sensing Receptor Car Casr Hcasr Parathyroid Cell Calcium-Sensing Receptor 1 Pcar1
Database Links	Reactome: R-HSA-416476 Reactome: R-HSA-418594 Reactome: R-HSA-420499
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-Extracellular Calcium-Sensing Receptor antibody Anti-Car antibody Anti-Casr antibody Anti-Hcasr antibody Anti-Parathyroid Cell Calcium-Sensing Receptor 1 antibody Anti-Pcar1 antibody Anti-CASR antibody Anti-GPRC2A antibody Anti-PCAR1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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