Anti-CASR antibody (854-903 aa) (STJ92031) STJ92031 上海玉博生物科技有限公司

Anti-CASR antibody (854-903 aa) (STJ92031)

简单介绍

Anti-CASR antibody (854-903 aa) (STJ92031)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Extracellular calcium-sensing receptor (854-903 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:5000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CASR
Gene ID:	846
Uniprot ID:	CASR_HUMAN
Immunogen Region:	854-903 aa
Specificity:	CaSR Polyclonal Antibody detects endogenous levels of CaSR protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human Calcium Sensing Receptor at the amino acid range 854-903

Post Translational Modifications	N-glycosylated. Ubiquitinated by RNF19A.which induces proteasomal degradation.
Function	G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation.
Protein Name	Extracellular Calcium-Sensing Receptor Car Casr Hcasr Parathyroid Cell Calcium-Sensing Receptor 1 Pcar1
Database Links	Reactome: R-HSA-416476 Reactome: R-HSA-418594 Reactome: R-HSA-420499
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-Extracellular Calcium-Sensing Receptor antibody Anti-Car antibody Anti-Casr antibody Anti-Hcasr antibody Anti-Parathyroid Cell Calcium-Sensing Receptor 1 antibody Anti-Pcar1 antibody Anti-CASR antibody Anti-GPRC2A antibody Anti-PCAR1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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