Human IL10 (IL10) Sandwich ELISA Kit (STJE0000007) STJE0000007-96 上海玉博生物科技有限公司

Human IL10 (IL10) Sandwich ELISA Kit (STJE0000007)

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产品名称：Human IL10 (IL10) Sandwich ELISA Kit (STJE0000007)
产品型号：STJE0000007-96
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human IL10 (IL10) Sandwich ELISA Kit (STJE0000007)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	3.9 pg/mL
Detection Limit:	312-2000 pg/mL
Short Description:	This IL10 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Conjugation:	Biotin
Storage Instruction:	Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time:	4 hours
Detection:	Colorimetric

Gene Symbol:	IL10
Gene ID:	3586
Uniprot ID:	IL10_HUMAN
Sample Type:	serum, plasma, cell culture supernates

Tissue Specificity	Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.
Post Translational Modifications
Function	Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling.
Protein Name	Interleukin-10 Il-10 Cytokine Synthesis Inhibitory Factor Csif
Database Links	Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-8950505 Reactome: R-HSA-9662834 Reactome: R-HSA-9664323
Cellular Localisation	Secreted
Alternative ELISA Names	Interleukin-10 ELISA kit Il-10 ELISA kit Cytokine Synthesis Inhibitory Factor ELISA kit Csif ELISA kit IL10 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human IL10 (IL10) Sandwich ELISA Kit (STJE0000007)