Anti-ATXN1 antibody (Internal) (STJ72025) STJ72025-100 上海玉博生物科技有限公司

Anti-ATXN1 antibody (Internal) (STJ72025)

简单介绍

Anti-ATXN1 antibody (Internal) (STJ72025)

产品描述

Host:	Goat
Applications:	Pep-ELISA
Reactivity:	Human/Dog/Pig
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-ATXN1 (Internal) is suitable for use in ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	ELISA-antibody detection limit dilution 1:64000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	ATXN1
Gene ID:	6310
Uniprot ID:	ATX1_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_000323.2
Specificity:	Reported variant NP_000323.2 and NP_001121636.1 represent identical protein.
Immunogen Sequence:	DLEVQQATHREASP

Post Translational Modifications	Ubiquitinated by UBE3A, leading to its degradation by the proteasome. The presence of expanded poly-Gln repeats in spinocerebellar ataxia 1 (SCA1) patients impairs ubiquitination and degradation, leading to accumulation of ATXN1 in neurons and subsequent toxicity. Phosphorylation at Ser-775 increases the pathogenicity of proteins with an expanded polyglutamine tract. Sumoylation is dependent on nuclear localization and phosphorylation at Ser-775. It is reduced in the presence of an expanded polyglutamine tract.
Function	Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development.
Protein Name	Ataxin-1 Spinocerebellar Ataxia Type 1 Protein
Cellular Localisation	Cytoplasm Nucleus Colocalizes With Usp7 In The Nucleus
Alternative Antibody Names	Anti-Ataxin-1 antibody Anti-Spinocerebellar Ataxia Type 1 Protein antibody Anti-ATXN1 antibody Anti-ATX1 antibody Anti-SCA1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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