Human IL1A (IL1A) Sandwich ELISA Kit (STJE0000019) STJE0000019-96 上海玉博生物科技有限公司

Human IL1A (IL1A) Sandwich ELISA Kit (STJE0000019)

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产品名称：Human IL1A (IL1A) Sandwich ELISA Kit (STJE0000019)
产品型号：STJE0000019-96
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human IL1A (IL1A) Sandwich ELISA Kit (STJE0000019)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	4 pg/mL
Detection Limit:	78-500 pg/ml
Short Description:	This IL1A Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Conjugation:	Biotin
Storage Instruction:	Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time:	4 hours
Detection:	Colorimetric

Gene Symbol:	IL1A
Gene ID:	3552
Uniprot ID:	IL1A_HUMAN
Sample Type:	serum, plasma and cell culture supernates

Tissue Specificity
Post Translational Modifications	Acetylated within its nuclear localization sequence, which impacts subcellular localization. Proteolytic processed by CAPN1 in a calcium-dependent manner. Cleavage from 31 kDa precursor to 18 kDa biologically active molecules. Phosphorylated. Phosphorylation greatly enhances susceptibility to digestion and promotes the conversion of pre-IL1A alpha to the biologically active IL1A.
Function	Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
Protein Name	Interleukin-1 Alpha Il-1 Alpha Hematopoietin-1
Database Links	Reactome: R-HSA-2559582 Reactome: R-HSA-448706 Reactome: R-HSA-5620971 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-9020702 Reactome: R-HSA-9660826
Cellular Localisation	Nucleus Cytoplasm Secreted The Lack Of A Specific Hydrophobic Segment In The Precursor Sequence Suggests That Il-1 Is Released By Damaged Cells Or Is Secreted By A Mechanism Differing From That Used For Other Secretory Proteins The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10 It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion Recruited To Dna Damage Sites And Secreted After Genotoxic Stress
Alternative ELISA Names	Interleukin-1 Alpha ELISA kit Il-1 Alpha ELISA kit Hematopoietin-1 ELISA kit IL1A ELISA kit IL1F1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human IL1A (IL1A) Sandwich ELISA Kit (STJE0000019)