Anti-CBX3 antibody (STJA0010016) STJA0010016 上海玉博生物科技有限公司

Anti-CBX3 antibody (STJA0010016)

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产品名称：Anti-CBX3 antibody (STJA0010016)
产品型号：STJA0010016
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CBX3 antibody (STJA0010016)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Chromobox protein homolog 3 is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CBX3
Gene ID:	11335
Uniprot ID:	CBX3_HUMAN
Specificity:	This antibody detects endogenous levels of HP1 gamma/CBX3 (citrulline R108) at Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from human HP1 gamma/CBX3 (citrulline R108)

Post Translational Modifications	Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
Function	Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs).
Protein Name	Chromobox Protein Homolog 3 Hech Heterochromatin Protein 1 Homolog Gamma Hp1 Gamma Modifier 2 Protein
Database Links	Reactome: R-HSA-427389 Reactome: R-HSA-73772 Reactome: R-HSA-8953750
Cellular Localisation	Nucleus Associates With Euchromatin And Is Largely Excluded From Constitutive Heterochromatin May Be Associated With Microtubules And Mitotic Poles During Mitosis (Potential)
Alternative Antibody Names	Anti-Chromobox Protein Homolog 3 antibody Anti-Hech antibody Anti-Heterochromatin Protein 1 Homolog Gamma antibody Anti-Hp1 Gamma antibody Anti-Modifier 2 Protein antibody Anti-CBX3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CBX3 antibody (STJA0010016)