Anti-CBX4 antibody (461-560) [S6MR] (STJ11102256) STJ11102256 上海玉博生物科技有限公司

Anti-CBX4 antibody (461-560) [S6MR] (STJ11102256)

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产品名称：Anti-CBX4 antibody (461-560) [S6MR] (STJ11102256)
产品型号：STJ11102256
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CBX4 antibody (461-560) [S6MR] (STJ11102256)

产品描述

Host:	Rabbit
Applications:	WB/IP
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-CBX4 (461-560) is suitable for use in Western Blot and Immunoprecipitation research applications.

Clonality:	Monoclonal
Clone ID:	S6MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IP 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CBX4
Gene ID:	8535
Uniprot ID:	CBX4_HUMAN
Immunogen Region:	461-560
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 461-560 of human CBX4 (O00257).
Immunogen Sequence:	EVILLDSDLDEPIDLRCVKT RSEAGEPPSSLQVKPETPAS AAVAVAAAAAPTTTAEKPPA EAQDEPAESLSEFKPFFGNI IITDVTANCLTVTFKEYVTV

Tissue Specificity	Ubiquitous.
Post Translational Modifications	Ubiquitinated. Ubiquitination regulates the function of the Polycomb group (PcG) multiprotein PRC1-like complex. Deubiquitinated by USP26. Phosphorylated on Thr-497 by HIPK2 upon DNA damage. This phosphorylation stimulates E3 SUMO-protein ligase activity and promotes sumoylation on Lys-494, as well as sumoylation of other target proteins, such as HNRNPK.
Function	E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3). Plays a role in the lineage differentiation of the germ layers in embryonic development.
Protein Name	E3 Sumo-Protein Ligase Cbx4 Chromobox Protein Homolog 4 Polycomb 2 Homolog Pc2 Hpc2
Database Links	Reactome: R-HSA-2559580 Reactome: R-HSA-3108214 Reactome: R-HSA-3899300 Reactome: R-HSA-4551638 Reactome: R-HSA-4570464 Reactome: R-HSA-4655427 Reactome: R-HSA-8939243 Reactome: R-HSA-8943724
Cellular Localisation	Nucleus Nucleus Speckle Localization To Nuclear Polycomb Bodies Is Required For Znf131 Sumoylation Localized In Distinct Foci On Chromatin
Alternative Antibody Names	Anti-E3 Sumo-Protein Ligase Cbx4 antibody Anti-Chromobox Protein Homolog 4 antibody Anti-Polycomb 2 Homolog antibody Anti-Pc2 antibody Anti-Hpc2 antibody Anti-CBX4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CBX4 antibody (461-560) [S6MR] (STJ11102256)