Anti-CBX5 antibody (1-191) (STJ114466) STJ114466 上海玉博生物科技有限公司

Anti-CBX5 antibody (1-191) (STJ114466)

简单介绍

Anti-CBX5 antibody (1-191) (STJ114466)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CBX5 (1-191) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CBX5
Gene ID:	23468
Uniprot ID:	CBX5_HUMAN
Immunogen Region:	1-191
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-191 of human HP1 alpha/HP1 alpha/CBX5 (NP_001120794.1).
Immunogen Sequence:	MGKKTKRTADSSSSEDEEEY VVEKVLDRRVVKGQVEYLLK WKGFSEEHNTWEPEKNLDCP ELISEFMKKYKKMKEGENNK PREKSESNKRKSNFSNSADD IKSKKKREQSNDIARGFERG LEPEKIIGATDSCGDLMFLM KWKDTDEADLVLAKEANVKC PQIVIAFYEERLTWHAYPED AENKEKETAKS

Post Translational Modifications	Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. Ubiquitinated.
Function	Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Protein Name	Chromobox Protein Homolog 5 Antigen P25 Heterochromatin Protein 1 Homolog Alpha Hp1 Alpha
Database Links	Reactome: R-HSA-4551638 Reactome: R-HSA-8953750 Reactome: R-HSA-983231
Cellular Localisation	Nucleus Chromosome Centromere Colocalizes With Hnrnpu In The Nucleus Component Of Centromeric And Pericentromeric Heterochromatin Associates With Chromosomes During Mitosis Associates Specifically With Chromatin During Metaphase And Anaphase Localizes To Sites Of Dna Damage
Alternative Antibody Names	Anti-Chromobox Protein Homolog 5 antibody Anti-Antigen P25 antibody Anti-Heterochromatin Protein 1 Homolog Alpha antibody Anti-Hp1 Alpha antibody Anti-CBX5 antibody Anti-HP1A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

产品目录