Anti-CCDC22 antibody (STJA0006893) STJA0006893 上海玉博生物科技有限公司

Anti-CCDC22 antibody (STJA0006893)

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产品名称：Anti-CCDC22 antibody (STJA0006893)
产品型号：STJA0006893
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CCDC22 antibody (STJA0006893)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Coiled-coil domain-containing protein 22 is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CCDC22
Gene ID:	28952
Uniprot ID:	CCD22_HUMAN
Specificity:	This antibody detects endogenous levels of CCDC22 at Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from human CCDC22

Function	Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation.the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery.the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface.
Protein Name	Coiled-Coil Domain-Containing Protein 22
Database Links	Reactome: R-HSA-8951664
Cellular Localisation	Endosome Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome
Alternative Antibody Names	Anti-Coiled-Coil Domain-Containing Protein 22 antibody Anti-CCDC22 antibody Anti-CXorf37 antibody Anti-JM1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CCDC22 antibody (STJA0006893)