Anti-AUP1 antibody (STJA0007335) STJA0007335 上海玉博生物科技有限公司

Anti-AUP1 antibody (STJA0007335)

简单介绍

Anti-AUP1 antibody (STJA0007335)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Lipid droplet-regulating VLDL assembly factor AUP1 is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	AUP1
Gene ID:	550
Uniprot ID:	AUP1_HUMAN
Specificity:	This antibody detects endogenous levels of AUP1 at Human, Rat
Immunogen:	Synthesized peptide derived from human AUP1

Post Translational Modifications	Monoubiquitinated and diubiquitinated. (Microbial infection) Not ubiquitinated following Dengue virus infection.
Function	Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Plays a role in lipid droplet formation. Induces lipid droplet clustering. Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation. Also required for the degradation of INSIG1, SREBF1 and SREBF2. Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB. (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles.
Protein Name	Lipid Droplet-Regulating Vldl Assembly Factor Aup1 Ancient Ubiquitous Protein 1
Cellular Localisation	Endoplasmic Reticulum Membrane Peripheral Membrane Protein Lipid Droplet Cytoplasmic Vesicle Autophagosome (Microbial Infection) Upon Dengue Virus Infection Relocates From Lipid Droplets To Autophagosomes
Alternative Antibody Names	Anti-Lipid Droplet-Regulating Vldl Assembly Factor Aup1 antibody Anti-Ancient Ubiquitous Protein 1 antibody Anti-AUP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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