Anti-AURKC antibody (1-100) (STJ110239) STJ110239 上海玉博生物科技有限公司

Anti-AURKC antibody (1-100) (STJ110239)

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产品名称：Anti-AURKC antibody (1-100) (STJ110239)
产品型号：STJ110239
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-AURKC antibody (1-100) (STJ110239)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-AURKC (1-100) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:100
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	AURKC
Gene ID:	6795
Uniprot ID:	AURKC_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human AURKC (NP_001015878.1).
Immunogen Sequence:	MSSPRAVVQLGKAQPAGEEL ATANQTAQQPSSPAMRRLTV DDFEIGRPLGKGKFGNVYLA RLKESHFIVALKVLFKSQIE KEGLEHQLRREIEIQAHLQH

Tissue Specificity	Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.
Function	Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Protein Name	Aurora Kinase C Aurora 3 Aurora/Ipl1-Related Kinase 3 Ark-3 Aurora-Related Kinase 3 Aurora/Ipl1/Eg2 Protein 2 Serine/Threonine-Protein Kinase 13 Serine/Threonine-Protein Kinase Aurora-C
Cellular Localisation	Nucleus Chromosome Centromere Cytoplasm Cytoskeleton Spindle Distributes In The Condensed Chromosomes During Prophase To Metaphase After Entering Anaphase There Is A Dissociation From Separated Chromosomes And A Redistribution To Midzone Microtubules And Finally Remains In The Midbody During Cytokinesis
Alternative Antibody Names	Anti-Aurora Kinase C antibody Anti-Aurora 3 antibody Anti-Aurora/Ipl1-Related Kinase 3 antibody Anti-Ark-3 antibody Anti-Aurora-Related Kinase 3 antibody Anti-Aurora/Ipl1/Eg2 Protein 2 antibody Anti-Serine/Threonine-Protein Kinase 13 antibody Anti-Serine/Threonine-Protein Kinase Aurora-C antibody Anti-AURKC antibody Anti-AIE2 antibody Anti-AIK3 antibody Anti-AIRK3 antibody Anti-ARK3 antibody Anti-STK13 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-AURKC antibody (1-100) (STJ110239)