Human IL23A (IL23A) Sandwich ELISA Kit (STJE0000090) STJE0000090-96 上海玉博生物科技有限公司

Human IL23A (IL23A) Sandwich ELISA Kit (STJE0000090)

简单介绍

Human IL23A (IL23A) Sandwich ELISA Kit (STJE0000090)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	15.6 pg/mL
Detection Limit:	312-2000 pg/mL
Short Description:	This IL23A Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Conjugation:	Biotin
Storage Instruction:	Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time:	4 hours
Detection:	Colorimetric

Gene Symbol:	IL23A
Gene ID:	51561
Uniprot ID:	IL23A_HUMAN
Sample Type:	serum, plasma and cell culture supernates

Tissue Specificity	Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
Post Translational Modifications
Function	Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.
Protein Name	Interleukin-23 Subunit Alpha Il-23 Subunit Alpha Il-23-A Interleukin-23 Subunit P19 Il-23p19
Database Links	Reactome: R-HSA-6785807 Reactome: R-HSA-9020933
Cellular Localisation	Secreted Secreted Upon Association With Il12b
Alternative ELISA Names	Interleukin-23 Subunit Alpha ELISA kit Il-23 Subunit Alpha ELISA kit Il-23-A ELISA kit Interleukin-23 Subunit P19 ELISA kit Il-23p19 ELISA kit IL23A ELISA kit SGRF ELISA kit UNQ2498 ELISA kit PRO5798 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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