Anti-CCKBR antibody (240-335) (STJ22926) STJ22926 上海玉博生物科技有限公司

Anti-CCKBR antibody (240-335) (STJ22926)

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产品名称：Anti-CCKBR antibody (240-335) (STJ22926)
产品型号：STJ22926
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CCKBR antibody (240-335) (STJ22926)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CCKBR (240-335) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CCKBR
Gene ID:	887
Uniprot ID:	GASR_HUMAN
Immunogen Region:	240-335
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 240-335 of human CCKBR (NP_795344.1).
Immunogen Sequence:	LISRELYLGLRFDGDSDSDS QSRVRNQGGLPGAVHQNGRC RPETGAVGEDSDGCYVQLPR SRPALELTALTAPGPGSGSR PTQAKLLAKKRVVRML

Tissue Specificity	Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
Function	Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.
Protein Name	Gastrin/Cholecystokinin Type B Receptor Cck-B Receptor Cck-Br Cholecystokinin-2 Receptor Cck2-R
Database Links	Reactome: R-HSA-375276 Reactome: R-HSA-416476 Reactome: R-HSA-881907
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-Gastrin/Cholecystokinin Type B Receptor antibody Anti-Cck-B Receptor antibody Anti-Cck-Br antibody Anti-Cholecystokinin-2 Receptor antibody Anti-Cck2-R antibody Anti-CCKBR antibody Anti-CCKRB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CCKBR antibody (240-335) (STJ22926)