Anti-CCL20 antibody (31-80 aa) (STJ98775) STJ98775 上海玉博生物科技有限公司

Anti-CCL20 antibody (31-80 aa) (STJ98775)

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产品名称：Anti-CCL20 antibody (31-80 aa) (STJ98775)
产品型号：STJ98775
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CCL20 antibody (31-80 aa) (STJ98775)

产品描述

Host:	Rabbit
Applications:	IHC/IF/ELISA
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-C-C motif chemokine 20 (31-80 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	IHC-P 1:50-200 ELISA 1:10000-20000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CCL20
Gene ID:	6364
Uniprot ID:	CCL20_HUMAN
Immunogen Region:	31-80 aa
Specificity:	The antibody detects endogenous MIP-3 Alpha
Immunogen:	Synthetic peptide from the human protein at the amino acid range 31-80

Post Translational Modifications	C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Function	Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213.
Protein Name	C-C Motif Chemokine 20 Beta-Chemokine Exodus-1 Cc Chemokine Larc Liver And Activation-Regulated Chemokine Macrophage Inflammatory Protein 3 Alpha Mip-3-Alpha Small-Inducible Cytokine A20 Cleaved Into - Ccl20(1-67 - Ccl20(1-64 - Ccl20(2-70
Database Links	Reactome: R-HSA-380108 Reactome: R-HSA-418594 Reactome: R-HSA-6783783
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-C-C Motif Chemokine 20 antibody Anti-Beta-Chemokine Exodus-1 antibody Anti-Cc Chemokine Larc antibody Anti-Liver And Activation-Regulated Chemokine antibody Anti-Macrophage Inflammatory Protein 3 Alpha antibody Anti-Mip-3-Alpha antibody Anti-Small-Inducible Cytokine A20 Cleaved Into - Ccl20(1-67 - Ccl20(1-64 - Ccl20(2-70 antibody Anti-CCL20 antibody Anti-LARC antibody Anti-MIP3A antibody Anti-SCYA20 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CCL20 antibody (31-80 aa) (STJ98775)