Anti-CCL22 antibody (25-93) (STJ22931) STJ22931 上海玉博生物科技有限公司

Anti-CCL22 antibody (25-93) (STJ22931)

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产品名称：Anti-CCL22 antibody (25-93) (STJ22931)
产品型号：STJ22931
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CCL22 antibody (25-93) (STJ22931)

产品描述

Host:	Rabbit
Applications:	IHC
Reactivity:	Human/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CCL22 (25-93) is suitable for use in Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CCL22
Gene ID:	6367
Uniprot ID:	CCL22_HUMAN
Immunogen Region:	25-93
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 25-93 of human CCL22 (NP_002981.2).
Immunogen Sequence:	GPYGANMEDSVCCRDYVRYR LPLRVVKHFYWTSDSCPRPG VVLLTFRDKEICADPRVPWV KMILNKLSQ

Tissue Specificity	Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.
Post Translational Modifications	The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.
Function	May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.
Protein Name	C-C Motif Chemokine 22 Cc Chemokine Stcp-1 Mdc(1-69 Macrophage-Derived Chemokine Small-Inducible Cytokine A22 Stimulated T-Cell Chemotactic Protein 1 Cleaved Into - Mdc(3-69 - Mdc(5-69 - Mdc(7-69
Database Links	Reactome: R-HSA-380108 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-C-C Motif Chemokine 22 antibody Anti-Cc Chemokine Stcp-1 antibody Anti-Mdc(1-69 antibody Anti-Macrophage-Derived Chemokine antibody Anti-Small-Inducible Cytokine A22 antibody Anti-Stimulated T-Cell Chemotactic Protein 1 Cleaved Into - Mdc(3-69 - Mdc(5-69 - Mdc(7-69 antibody Anti-CCL22 antibody Anti-MDC antibody Anti-SCYA22 antibody Anti-A-152E5.1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CCL22 antibody (25-93) (STJ22931)