Anti-AXIN1 antibody (C-Term) (STJ70148) STJ70148-100 上海玉博生物科技有限公司

Anti-AXIN1 antibody (C-Term) (STJ70148)

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产品名称：Anti-AXIN1 antibody (C-Term) (STJ70148)
产品型号：STJ70148-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-AXIN1 antibody (C-Term) (STJ70148)

产品描述

Host:	Goat
Applications:	Pep-ELISA/IHC
Reactivity:	Human/Mouse/Rat/Dog/Cow
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-AXIN1 (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	IHC-Recommended concentration, 3-5µg/ml ELISA-antibody detection limit dilution 1:128000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	AXIN1
Gene ID:	8312
Uniprot ID:	AXIN1_HUMAN
Immunogen Region:	C-Term
Accession Number:	NP_003493.1; NP_851393.1
Specificity:	This antibody is expected to recognise both reported isoforms.
Immunogen Sequence:	FEEKIIGKVEKVD

Post Translational Modifications	Phosphorylation and dephosphorylation of AXIN1 regulates assembly and function of the beta-catenin complex. Phosphorylated by CK1 and GSK3B. Dephosphorylated by PPP1CA and PPP2CA. Phosphorylation by CK1 enhances binding of GSK3B to AXIN1. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination at 'Lys-48' and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Sumoylation at Lys-857 and Lys-860 prevents ubiquitination and degradation. Sumoylation is required for AXIN1-mediated JNK activation. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important for nuclear accumulation during Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription. Ubiquitination by SIAH1 and SIAH2 induces its proteasomal degradation as part of the activation of the Wnt signaling pathway.
Function	Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects.down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation.
Protein Name	Axin-1 Axis Inhibition Protein 1 Haxin
Database Links	Reactome: R-HSA-195253 Reactome: R-HSA-196299 Reactome: R-HSA-201681 Reactome: R-HSA-4641257 Reactome: R-HSA-4641262 Reactome: R-HSA-5339716 Reactome: R-HSA-5358747 Reactome: R-HSA-5358749 Reactome: R-HSA-5358751 Reactome: R-HSA-5358752 Reactome: R-HSA-5467337 Reactome: R-HSA-5467340 Reactome: R-HSA-5467348 Reactome: R-HSA-5689880 Reactome: R-HSA-8931987 Reactome: R-HSA-8939256 Reactome: R-HSA-9018519
Cellular Localisation	Cytoplasm Nucleus Membrane Cell Membrane Macf1 Is Required For Its Translocation To Cell Membrane On Uv Irradiation Translocates To The Nucleus And Colocalizes With Daax
Alternative Antibody Names	Anti-Axin-1 antibody Anti-Axis Inhibition Protein 1 antibody Anti-Haxin antibody Anti-AXIN1 antibody Anti-AXIN antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-AXIN1 antibody (C-Term) (STJ70148)