Human IP10 (Interferon Gamma Induced Protein 10kDa) Sandwich ELISA Kit Ready-To-Use (STJE0016421) STJE0016421 上海玉博生物科技有限公司

Human IP10 (Interferon Gamma Induced Protein 10kDa) Sandwich ELISA Kit Ready-To-Use (STJE0016421)

如果您对该产品感兴趣的话，可以
产品名称：Human IP10 (Interferon Gamma Induced Protein 10kDa) Sandwich ELISA Kit Ready-To-Use (STJE0016421)
产品型号：STJE0016421
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human IP10 (Interferon Gamma Induced Protein 10kDa) Sandwich ELISA Kit Ready-To-Use (STJE0016421)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	12.4pg/mL
Detection Limit:	31.2-2000pg/mL
Short Description:	This IP10 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	CXCL10
Gene ID:	3627
Uniprot ID:	CXL10_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Mainly secreted by monocytes, endothelial cells as well as fibroblasts. Expressed by epithelial cells in thymus. Microglial cells produce CXCL10 in response to viral stimulation.
Post Translational Modifications	Several proteases can mediate post-secretion cleavages. DPP4 cleaves CXCL10 on its N-terminal 2 amino acids leading to an antagonist form of CXCL10. This dominant negative form is capable of binding CXCR3 but does not induce signaling. MMP9 cleaves 9 amino acids instead.
Function	Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization.
Protein Name	C-X-C Motif Chemokine 10 10 Kda Interferon Gamma-Induced Protein Gamma-Ip10 Ip-10 Small-Inducible Cytokine B10 Cleaved Into - Cxcl10(1-73
Database Links	Reactome: R-HSA-380108 Reactome: R-HSA-418594 Reactome: R-HSA-6783783
Cellular Localisation	Secreted
Alternative ELISA Names	C-X-C Motif Chemokine 10 ELISA kit 10 Kda Interferon Gamma-Induced Protein ELISA kit Gamma-Ip10 ELISA kit Ip-10 ELISA kit Small-Inducible Cytokine B10 Cleaved Into - Cxcl10(1-73 ELISA kit CXCL10 ELISA kit INP10 ELISA kit SCYB10 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Human IP10 (Interferon Gamma Induced Protein 10kDa) Sandwich ELISA Kit Ready-To-Use (STJE0016421)