Anti-CCL5 antibody (18-91) (STJ27597) STJ27597 上海玉博生物科技有限公司

Anti-CCL5 antibody (18-91) (STJ27597)

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产品名称：Anti-CCL5 antibody (18-91) (STJ27597)
产品型号：STJ27597
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CCL5 antibody (18-91) (STJ27597)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-RANTES (18-91) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CCL5
Gene ID:	6352
Uniprot ID:	CCL5_HUMAN
Immunogen Region:	18-91
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 18-91 of human CCL5/RANTES (NP_002976.2).
Immunogen Sequence:	CAPASASPYSSDTTPCCFAY IARPLPRAHIKEYFYTSGKC SNPAVVFVTRKNRQVCANPE KKWVREYINSLEMS

Tissue Specificity	Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.
Post Translational Modifications	N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells. N-terminal processed form RANTES(4-68) is produced by proteolytic cleavage by cathepsin CTSG. The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
Function	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
Protein Name	C-C Motif Chemokine 5 Eocp Eosinophil Chemotactic Cytokine Sis-Delta Small-Inducible Cytokine A5 T Cell-Specific Protein P228 Tcp228 T-Cell-Specific Protein Rantes Cleaved Into - Rantes(3-68 - Rantes(4-68
Database Links	Reactome: R-HSA-380108 Reactome: R-HSA-418594 Reactome: R-HSA-6783783
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-C-C Motif Chemokine 5 antibody Anti-Eocp antibody Anti-Eosinophil Chemotactic Cytokine antibody Anti-Sis-Delta antibody Anti-Small-Inducible Cytokine A5 antibody Anti-T Cell-Specific Protein P228 antibody Anti-Tcp228 antibody Anti-T-Cell-Specific Protein Rantes Cleaved Into - Rantes(3-68 - Rantes(4-68 antibody Anti-CCL5 antibody Anti-D17S136E antibody Anti-SCYA5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CCL5 antibody (18-91) (STJ27597)