Anti-CCNC antibody (1-283) (STJ115570) STJ115570 上海玉博生物科技有限公司

Anti-CCNC antibody (1-283) (STJ115570)

简单介绍

Anti-CCNC antibody (1-283) (STJ115570)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CCNC (1-283) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CCNC
Gene ID:	892
Uniprot ID:	CCNC_HUMAN
Immunogen Region:	1-283
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human Cyclin C (NP_005181.2).
Immunogen Sequence:	MAGNFWQSSHYLQWILDKQD LLKERQKDLKFLSEEEYWKL QIFFTNVIQALGEHLKLRQQ VIATATVYFKRFYARYSLKS IDPVLMAPTCVFLASKVEEF GVVSNTRLIAAATSVLKTRF SYAFPKEFPYRMNHILECEF YLLELMDCCLIVYHPYRPLL QYVQDMGQEDMLLPLAWRIV NDTYRTDLCLLYPPFMIALA CLHVACVVQQKDARQWFAEL SVDMEKILEIIRVILKLYE

Tissue Specificity	Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
Function	Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Protein Name	Cyclin-C Srb11 Homolog Hsrb11
Database Links	Reactome: R-HSA-1989781 Reactome: R-HSA-2122947 Reactome: R-HSA-212436 Reactome: R-HSA-2173796 Reactome: R-HSA-2644606 Reactome: R-HSA-2894862 Reactome: R-HSA-381340
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Cyclin-C antibody Anti-Srb11 Homolog antibody Anti-Hsrb11 antibody Anti-CCNC antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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