Human IRAK4 (Interleukin 1 Receptor Associated Kinase 4) Sandwich ELISA Kit Ready-To-Use (STJE0016434) STJE0016434 上海玉博生物科技有限公司

Human IRAK4 (Interleukin 1 Receptor Associated Kinase 4) Sandwich ELISA Kit Ready-To-Use (STJE0016434)

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产品名称：Human IRAK4 (Interleukin 1 Receptor Associated Kinase 4) Sandwich ELISA Kit Ready-To-Use (STJE0016434)
产品型号：STJE0016434
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human IRAK4 (Interleukin 1 Receptor Associated Kinase 4) Sandwich ELISA Kit Ready-To-Use (STJE0016434)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.53ng/mL
Detection Limit:	1.56-100ng/mL
Short Description:	This IRAK4 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	IRAK4
Gene ID:	51135
Uniprot ID:	IRAK4_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Phosphorylated.
Function	Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.
Protein Name	Interleukin-1 Receptor-Associated Kinase 4 Irak-4 Renal Carcinoma Antigen Ny-Ren-64
Database Links	Reactome: R-HSA-1257604 Reactome: R-HSA-166058 Reactome: R-HSA-5603037 Reactome: R-HSA-5603041 Reactome: R-HSA-6811558 Reactome: R-HSA-9020702 Reactome: R-HSA-975110 Reactome: R-HSA-975138 Reactome: R-HSA-975155 Reactome: R-HSA-975871
Cellular Localisation	Cytoplasm
Alternative ELISA Names	Interleukin-1 Receptor-Associated Kinase 4 ELISA kit Irak-4 ELISA kit Renal Carcinoma Antigen Ny-Ren-64 ELISA kit IRAK4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human IRAK4 (Interleukin 1 Receptor Associated Kinase 4) Sandwich ELISA Kit Ready-To-Use (STJE0016434)