Anti-CCND3 antibody (202-292) [S0MR] (STJ11101980) STJ11101980 上海玉博生物科技有限公司

Anti-CCND3 antibody (202-292) [S0MR] (STJ11101980)

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产品名称：Anti-CCND3 antibody (202-292) [S0MR] (STJ11101980)
产品型号：STJ11101980
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CCND3 antibody (202-292) [S0MR] (STJ11101980)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-Cyclin D3 (202-292) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	S0MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CCND3
Gene ID:	896
Uniprot ID:	CCND3_HUMAN
Immunogen Region:	202-292
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 202-292 of human Cyclin D3 (P30281).
Immunogen Sequence:	MIATGSIGAAVQGLGACSMS GDELTELLAGITGTEVDCLR ACQEQIEAALRESLREASQT SSSPAPKAPRGSSSQGPSQT STPTDVTAIHL

Post Translational Modifications	Phosphorylation at Thr-283 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex. Ubiquitinated by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation: ubiquitination is dependent on Thr-283 phosphorylation. The DCX(AMBRA1) complex represents the major regulator of CCND3 stability during the G1/S transition. Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
Function	Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4.
Protein Name	G1/S-Specific Cyclin-D3
Database Links	Reactome: R-HSA-381340 Reactome: R-HSA-5687128 Reactome: R-HSA-69231 Reactome: R-HSA-8934593 Reactome: R-HSA-9661069 Reactome: R-HSA-9754119
Cellular Localisation	Nucleus Cytoplasm
Alternative Antibody Names	Anti-G1/S-Specific Cyclin-D3 antibody Anti-CCND3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CCND3 antibody (202-292) [S0MR] (STJ11101980)