Anti-CCNF antibody (737-786 aa) (STJ92545) STJ92545 上海玉博生物科技有限公司

Anti-CCNF antibody (737-786 aa) (STJ92545)

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产品名称：Anti-CCNF antibody (737-786 aa) (STJ92545)
产品型号：STJ92545
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CCNF antibody (737-786 aa) (STJ92545)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cyclin-F (737-786 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CCNF
Gene ID:	899
Uniprot ID:	CCNF_HUMAN
Immunogen Region:	737-786 aa
Specificity:	Cyclin F Polyclonal Antibody detects endogenous levels of Cyclin F protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human Cyclin F at the amino acid range 737-786

Post Translational Modifications	Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation depends on the C-terminal PEST sequence. Phosphorylated just before cells enter into mitosis. Ubiquitinated by the anaphase-promoting complex (APC/C).leading to its degradation by the proteasome.
Function	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle. Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability. Mediates the ubiquitination and proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. In G2, mediates the ubiquitination and subsequent degradation of ribonucleotide reductase RRM2, thereby maintaining a balanced pool of dNTPs and genome integrity. In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability. Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry. May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB.
Protein Name	Cyclin-F F-Box Only Protein 1
Database Links	Reactome: R-HSA-8951664 Reactome: R-HSA-983168
Cellular Localisation	Nucleus Cytoplasm Perinuclear Region Cytoskeleton Microtubule Organizing Center Centrosome Centriole Localization To The Centrosome Is Rare In S Phase Cells And Increases In G2 Cells Localizes To Both The Mother And Daughter Centrioles Localization To Centrosomes Is Not Dependent On Cp110 Localizes To The Nucleus In G2 Phase
Alternative Antibody Names	Anti-Cyclin-F antibody Anti-F-Box Only Protein 1 antibody Anti-CCNF antibody Anti-FBX1 antibody Anti-FBXO1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CCNF antibody (737-786 aa) (STJ92545)