Human JAK3 (Janus Kinase 3) Sandwich ELISA Kit (STJE0010117) STJE0010117 上海玉博生物科技有限公司

Human JAK3 (Janus Kinase 3) Sandwich ELISA Kit (STJE0010117)

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产品名称：Human JAK3 (Janus Kinase 3) Sandwich ELISA Kit (STJE0010117)
产品型号：STJE0010117
产品展商：ST john's laboratory
产品文档：无相关文档

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Human JAK3 (Janus Kinase 3) Sandwich ELISA Kit (STJE0010117)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.066ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This JAK3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	JAK3
Gene ID:	3718
Uniprot ID:	JAK3_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins.
Post Translational Modifications	Tyrosine phosphorylated in response to IL-2 and IL-4. Dephosphorylation of Tyr-980 and Tyr-981 by PTPN2 negatively regulates cytokine-mediated signaling (Probable).
Function	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
Protein Name	Tyrosine-Protein Kinase Jak3 Janus Kinase 3 Jak-3 Leukocyte Janus Kinase L-Jak
Database Links	Reactome: R-HSA-1266695 Reactome: R-HSA-201556 Reactome: R-HSA-5673001 Reactome: R-HSA-6785807 Reactome: R-HSA-8854691 Reactome: R-HSA-8983432 Reactome: R-HSA-8985947 Reactome: R-HSA-9020558 Reactome: R-HSA-9020958 Reactome: R-HSA-912526 Reactome: R-HSA-9679191
Cellular Localisation	Endomembrane System Peripheral Membrane Protein Cytoplasm
Alternative ELISA Names	Tyrosine-Protein Kinase Jak3 ELISA kit Janus Kinase 3 ELISA kit Jak-3 ELISA kit Leukocyte Janus Kinase ELISA kit L-Jak ELISA kit JAK3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human JAK3 (Janus Kinase 3) Sandwich ELISA Kit (STJE0010117)