Human KARS (Lysyl tRNA Synthetase) Sandwich ELISA Kit (STJE0010132) STJE0010132 上海玉博生物科技有限公司

Human KARS (Lysyl tRNA Synthetase) Sandwich ELISA Kit (STJE0010132)

简单介绍

Human KARS (Lysyl tRNA Synthetase) Sandwich ELISA Kit (STJE0010132)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.082ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This KARS Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	KARS1
Gene ID:	3735
Uniprot ID:	SYK_HUMAN
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Phosphorylated on a serine residue after mast cell stimulation with immunoglobulin E (IgE).
Function	Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation.
Protein Name	Lysine--Trna Ligase Lysyl-Trna Synthetase Lysrs
Database Links	Reactome: R-HSA-2408522 Reactome: R-HSA-379716 Reactome: R-HSA-379726
Cellular Localisation	Isoform Cytoplasmic: Cytoplasm Cytosol Cytoplasm Nucleus Cell Membrane Peripheral Membrane Protein Secreted Secretion Is Induced By Tnf-Alpha Cytosolic In Quiescent Mast Cells Translocates Into The Nucleus In Response To Mast Cell Activation By Immunoglobulin E Isoform Mitochondrial: Mitochondrion
Alternative ELISA Names	Lysine--Trna Ligase ELISA kit Lysyl-Trna Synthetase ELISA kit Lysrs ELISA kit KARS1 ELISA kit KARS ELISA kit KIAA0070 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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