Human KCC2 (Potassium Chloride Cotransporters 2) Sandwich ELISA Kit (STJE0010135) STJE0010135 上海玉博生物科技有限公司

Human KCC2 (Potassium Chloride Cotransporters 2) Sandwich ELISA Kit (STJE0010135)

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产品名称：Human KCC2 (Potassium Chloride Cotransporters 2) Sandwich ELISA Kit (STJE0010135)
产品型号：STJE0010135
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human KCC2 (Potassium Chloride Cotransporters 2) Sandwich ELISA Kit (STJE0010135)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.107ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This KCC2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	SLC12A5
Gene ID:	57468
Uniprot ID:	S12A5_HUMAN
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Brain specific. Detected in neuronal cells.
Post Translational Modifications	Phosphorylated at Thr-929 and Thr-1030 by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4), inhibiting the potassium-chloride cotransport activity.
Function	Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.
Protein Name	Solute Carrier Family 12 Member 5 Electroneutral Potassium-Chloride Cotransporter 2 K-Cl Cotransporter 2 Hkcc2 Neuronal K-Cl Cotransporter
Database Links	Reactome: R-HSA-426117
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Cell Projection Dendrite Detected On Dendrites But Not On Axons Of Spinal Cord Neurons And At Gphn-Positive Inhibitory Synapses
Alternative ELISA Names	Solute Carrier Family 12 Member 5 ELISA kit Electroneutral Potassium-Chloride Cotransporter 2 ELISA kit K-Cl Cotransporter 2 ELISA kit Hkcc2 ELISA kit Neuronal K-Cl Cotransporter ELISA kit SLC12A5 ELISA kit KCC2 ELISA kit KIAA1176 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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