Human KDM4A (Lysine Specific Demethylase 4A) Sandwich ELISA Kit Ready-To-Use (STJE0016528) STJE0016528 上海玉博生物科技有限公司

Human KDM4A (Lysine Specific Demethylase 4A) Sandwich ELISA Kit Ready-To-Use (STJE0016528)

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产品名称：Human KDM4A (Lysine Specific Demethylase 4A) Sandwich ELISA Kit Ready-To-Use (STJE0016528)
产品型号：STJE0016528
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human KDM4A (Lysine Specific Demethylase 4A) Sandwich ELISA Kit Ready-To-Use (STJE0016528)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.128ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This KDM4A Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	KDM4A
Gene ID:	9682
Uniprot ID:	KDM4A_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Ubiquitous.
Post Translational Modifications	Ubiquitinated by RNF8 and RNF168 following DNA damage, leading to its degradation. Degradation promotes accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited.
Function	Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.
Protein Name	Lysine-Specific Demethylase 4a Jmjc Domain-Containing Histone Demethylation Protein 3a Jumonji Domain-Containing Protein 2a Histone H3-Trimethyl-L-Lysine(36 Demethylase 4a Histone H3-Trimethyl-L-Lysine(9 Demethylase 4a
Database Links	Reactome: R-HSA-3214842 Reactome: R-HSA-5693565 Reactome: R-HSA-9029569
Cellular Localisation	Nucleus
Alternative ELISA Names	Lysine-Specific Demethylase 4a ELISA kit Jmjc Domain-Containing Histone Demethylation Protein 3a ELISA kit Jumonji Domain-Containing Protein 2a ELISA kit Histone H3-Trimethyl-L-Lysine(36 Demethylase 4a ELISA kit Histone H3-Trimethyl-L-Lysine(9 Demethylase 4a ELISA kit KDM4A ELISA kit JHDM3A ELISA kit JMJD2 ELISA kit JMJD2A ELISA kit KIAA0677 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human KDM4A (Lysine Specific Demethylase 4A) Sandwich ELISA Kit Ready-To-Use (STJE0016528)