Anti-CCNT1 antibody (220-320) (STJ22961) STJ22961 上海玉博生物科技有限公司

Anti-CCNT1 antibody (220-320) (STJ22961)

如果您对该产品感兴趣的话，可以
产品名称：Anti-CCNT1 antibody (220-320) (STJ22961)
产品型号：STJ22961
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CCNT1 antibody (220-320) (STJ22961)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CCNT1 (220-320) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:1000-1:5000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CCNT1
Gene ID:	904
Uniprot ID:	CCNT1_HUMAN
Immunogen Region:	220-320
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 220-320 of human Cyclin T1 (NP_001231.2).
Immunogen Sequence:	HWWEYVDATVTLELLDELTH EFLQILEKTPNRLKRIWNWR ACEAAKKTKADDRGTDEKTS EQTILNMISQSSSDTTIAGL MSMSTSTTSAVPSLPVSEES S

Tissue Specificity	Ubiquitously expressed.
Post Translational Modifications	ADP-ribosylation on serine residues by PARP1 in response to DNA damage disrupts the phase separation activity of CCNT1, thereby preventing activation of CDK9.
Function	Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II. (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.
Protein Name	Cyclin-T1 Cyct1 Cyclin-T
Database Links	Reactome: R-HSA-112382 Reactome: R-HSA-167152 Reactome: R-HSA-167200 Reactome: R-HSA-167238 Reactome: R-HSA-167243 Reactome: R-HSA-167246 Reactome: R-HSA-167287 Reactome: R-HSA-167290 Reactome: R-HSA-176034 Reactome: R-HSA-2173796 Reactome: R-HSA-674695 Reactome: R-HSA-6796648 Reactome: R-HSA-6807505 Reactome: R-HSA-75955 Reactome: R-HSA-9018519
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Cyclin-T1 antibody Anti-Cyct1 antibody Anti-Cyclin-T antibody Anti-CCNT1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-CCNT1 antibody (220-320) (STJ22961)