Anti-CCR2/CKR2 antibody (1-100) [S6MR] (STJ11103486) STJ11103486 上海玉博生物科技有限公司

Anti-CCR2/CKR2 antibody (1-100) [S6MR] (STJ11103486)

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产品名称：Anti-CCR2/CKR2 antibody (1-100) [S6MR] (STJ11103486)
产品型号：STJ11103486
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CCR2/CKR2 antibody (1-100) [S6MR] (STJ11103486)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-CCR2/CKR2 (1-100) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	S6MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CCR2
Gene ID:	729230
Uniprot ID:	CCR2_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR2/CKR2 (P41597).
Immunogen Sequence:	MLSTSRSRFIRNTNESGEEV TTFFDYDYGAPCHKFDVKQI GAQLLPPLYSLVFIFGFVGN MLVVLILINCKKLKCLTDIY LLNLAISDLLFLITLPLWAH

Tissue Specificity	Expressed by monocytes and IL2-activated NK cells.
Post Translational Modifications	N-glycosylated. Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer.
Function	Key functional receptor for CCL2 but can also bind CCL7 and CCL12. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B. Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation. Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression.signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. Mediates the recruitment of macrophages and monocytes to the injury site following brain injury. (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.
Protein Name	C-C Chemokine Receptor Type 2 C-C Ckr-2 Cc-Ckr-2 Ccr-2 Ccr2 Monocyte Chemoattractant Protein 1 Receptor Mcp-1-R Cd Antigen Cd192
Database Links	Reactome: R-HSA-1461957 Reactome: R-HSA-380108 Reactome: R-HSA-418594 Reactome: R-HSA-6783783
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein The Chemoattractant Receptors Are Distributed Throughout The Cell Surface After Stimulation With A Ligand Such As Ccl2 They Are Rapidly Recruited Into Microdomain Clusters At The Cell Membrane
Alternative Antibody Names	Anti-C-C Chemokine Receptor Type 2 antibody Anti-C-C Ckr-2 antibody Anti-Cc-Ckr-2 antibody Anti-Ccr-2 antibody Anti-Ccr2 antibody Anti-Monocyte Chemoattractant Protein 1 Receptor antibody Anti-Mcp-1-R antibody Anti-Cd Antigen Cd192 antibody Anti-CCR2 antibody Anti-CMKBR2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CCR2/CKR2 antibody (1-100) [S6MR] (STJ11103486)