Human KLF4 (Kruppel Like Factor 4, Gut) Sandwich ELISA Kit Ready-To-Use (STJE0016565) STJE0016565 上海玉博生物科技有限公司

Human KLF4 (Kruppel Like Factor 4, Gut) Sandwich ELISA Kit Ready-To-Use (STJE0016565)

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产品名称：Human KLF4 (Kruppel Like Factor 4, Gut) Sandwich ELISA Kit Ready-To-Use (STJE0016565)
产品型号：STJE0016565
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human KLF4 (Kruppel Like Factor 4, Gut) Sandwich ELISA Kit Ready-To-Use (STJE0016565)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.060ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This KLF4 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	KLF4
Gene ID:	9314
Uniprot ID:	KLF4_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Ubiquitinated. 'Lys-48'-linked ubiquitinated and targeted for proteasomal degradation by the SCF(BTRC) E3 ubiquitin-protein ligase complex, thereby negatively regulating cell pluripotency maintenance and embryogenesis. Polyglutamylated by TTLL1 and TTLL4 at Glu-411, which inhibits KLF4 binding with E3 ligase component BTRC, thereby impeding ubiquitination. Deglutamylated by CCP1 and CCP6.deglutamylation promotes KLF4 ubiquitination. KLF4 glutamylation state plays a critical role in the regulation of its function in cell reprogramming, pluripotency maintenance and embryogenesis.
Function	Transcription factor.can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
Protein Name	Krueppel-Like Factor 4 Epithelial Zinc Finger Protein Ezf Gut-Enriched Krueppel-Like Factor
Database Links	Reactome: R-HSA-381340 Reactome: R-HSA-422085 Reactome: R-HSA-452723 Reactome: R-HSA-9617828
Cellular Localisation	Nucleus Cytoplasm
Alternative ELISA Names	Krueppel-Like Factor 4 ELISA kit Epithelial Zinc Finger Protein Ezf ELISA kit Gut-Enriched Krueppel-Like Factor ELISA kit KLF4 ELISA kit EZF ELISA kit GKLF ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human KLF4 (Kruppel Like Factor 4, Gut) Sandwich ELISA Kit Ready-To-Use (STJE0016565)