Human KLK6 (Kallikrein 6) Sandwich ELISA Kit Ready-To-Use (STJE0016585) STJE0016585 上海玉博生物科技有限公司

Human KLK6 (Kallikrein 6) Sandwich ELISA Kit Ready-To-Use (STJE0016585)

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产品名称：Human KLK6 (Kallikrein 6) Sandwich ELISA Kit Ready-To-Use (STJE0016585)
产品型号：STJE0016585
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human KLK6 (Kallikrein 6) Sandwich ELISA Kit Ready-To-Use (STJE0016585)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.126ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This KLK6 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	KLK6
Gene ID:	5653
Uniprot ID:	KLK6_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates, cerebrospinal fluid, breast milk or other biological fluids.

Tissue Specificity	In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.
Post Translational Modifications	Inactivated by autolytic cleavage after Arg-80.
Function	Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
Protein Name	Kallikrein-6 Neurosin Protease M Sp59 Serine Protease 18 Serine Protease 9 Zyme
Database Links
Cellular Localisation	Secreted Nucleus Nucleolus Cytoplasm Mitochondrion Microsome In Brain Detected In The Nucleus Of Glial Cells And In The Nucleus And Cytoplasm Of Neurons Detected In The Mitochondrial And Microsomal Fractions Of Hek-293 Cells And Released Into The Cytoplasm Following Cell Stress
Alternative ELISA Names	Kallikrein-6 ELISA kit Neurosin ELISA kit Protease M ELISA kit Sp59 ELISA kit Serine Protease 18 ELISA kit Serine Protease 9 ELISA kit Zyme ELISA kit KLK6 ELISA kit PRSS18 ELISA kit PRSS9 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human KLK6 (Kallikrein 6) Sandwich ELISA Kit Ready-To-Use (STJE0016585)