Anti-BATF antibody (C-Term) (STJ72996) STJ72996-100 上海玉博生物科技有限公司

Anti-BATF antibody (C-Term) (STJ72996)

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产品名称：Anti-BATF antibody (C-Term) (STJ72996)
产品型号：STJ72996-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BATF antibody (C-Term) (STJ72996)

产品描述

Host:	Goat
Applications:	Pep-ELISA
Reactivity:	Human/Mouse/Rat/Dog/Pig/Cow
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BATF (C-Term) is suitable for use in ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	ELISA-antibody detection limit dilution 1:128000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	BATF
Gene ID:	10538
Uniprot ID:	BATF_HUMAN
Immunogen Region:	C-Term
Accession Number:	NP_006390.1
Immunogen Sequence:	EVVYSAHAFHQPHVS

Post Translational Modifications	Phosphorylated on serine and threonine residues and at least one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA binding activity and transforms it as a negative regulator of AP-1 mediated transcription. Phosphorylated.
Function	AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGACGTCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs.
Protein Name	Basic Leucine Zipper Transcriptional Factor Atf-Like B-Cell-Activating Transcription Factor B-Atf Sf-Ht-Activated Gene 2 Protein Sfa-2
Database Links	Reactome: R-HSA-6785807
Cellular Localisation	Nucleus Cytoplasm Present In The Nucleus And Cytoplasm But Shows Increased Nuclear Translocation After Activation Of T-Cells
Alternative Antibody Names	Anti-Basic Leucine Zipper Transcriptional Factor Atf-Like antibody Anti-B-Cell-Activating Transcription Factor antibody Anti-B-Atf antibody Anti-Sf-Ht-Activated Gene 2 Protein antibody Anti-Sfa-2 antibody Anti-BATF antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BATF antibody (C-Term) (STJ72996)