Anti-CD11a/ITGAL antibody [R7-1] {AF488} (STJA0002190) STJA0002190 上海玉博生物科技有限公司

Anti-CD11a/ITGAL antibody [R7-1] {AF488} (STJA0002190)

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产品名称：Anti-CD11a/ITGAL antibody [R7-1] {AF488} (STJA0002190)
产品型号：STJA0002190
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD11a/ITGAL antibody [R7-1] {AF488} (STJA0002190)

产品描述

Host:	Mouse
Applications:	FC
Reactivity:	Human
Note:	FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Integrin alpha-L is suitable for use in Flow Cytometry research applications.

Clonality:	Monoclonal
Clone ID:	R7-1
Conjugation:	AF488
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	ITGAL
Gene ID:	3683
Uniprot ID:	ITAL_HUMAN

Tissue Specificity	Leukocytes.
Post Translational Modifications	In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
Function	Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Protein Name	Integrin Alpha-L Cd11 Antigen-Like Family Member A Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain Lfa-1a Leukocyte Function-Associated Molecule 1 Alpha Chain Cd Antigen Cd11a
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-202733 Reactome: R-HSA-216083 Reactome: R-HSA-6798695 Reactome: R-HSA-8949275
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-Integrin Alpha-L antibody Anti-Cd11 Antigen-Like Family Member A antibody Anti-Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain antibody Anti-Lfa-1a antibody Anti-Leukocyte Function-Associated Molecule 1 Alpha Chain antibody Anti-Cd Antigen Cd11a antibody Anti-ITGAL antibody Anti-CD11A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD11a/ITGAL antibody [R7-1] {AF488} (STJA0002190)