Human LCN2 (Neutrophil gelatinase-associated lipocalin) CLIA Kit (STJC0000087) STJC0000087 上海玉博生物科技有限公司

Human LCN2 (Neutrophil gelatinase-associated lipocalin) CLIA Kit (STJC0000087)

如果您对该产品感兴趣的话，可以
产品名称：Human LCN2 (Neutrophil gelatinase-associated lipocalin) CLIA Kit (STJC0000087)
产品型号：STJC0000087
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human LCN2 (Neutrophil gelatinase-associated lipocalin) CLIA Kit (STJC0000087)

产品描述

Applications:	CLIA
Reactivity:	Human
Note:	FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Sensitivity:	18.75pg/mL
Detection Limit:	31.25~2000pg/mL
Short Description:	This human LCN2 kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.

Storage Instruction:	If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
Assay Time:	3.5h
Detection:	Chemiluminescence

Gene Symbol:	LCN2
Gene ID:	3934
Uniprot ID:	NGAL_HUMAN
Specificity:	This kit recognizes Human NGAL in samples. No significant cross-reactivity or interference between Human NGAL and analogues was observed.
Sample Type:	Serum, plasma and other biological fluids

Tissue Specificity	Detected in neutrophils (at protein level). Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Expressed in the medullary tubules of the kidney. Not found in the small intestine or peripheral blood leukocytes.
Function	Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity.limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberculosis.
Protein Name	Neutrophil Gelatinase-Associated Lipocalin Ngal 25 Kda Alpha-2-Microglobulin-Related Subunit Of Mmp-9 Lipocalin-2 Oncogene 24p3 Siderocalin P25
Database Links	Reactome: R-HSA-6785807 Reactome: R-HSA-6798695 Reactome: R-HSA-6799990 Reactome: R-HSA-917937
Cellular Localisation	Secreted Cytoplasmic Granule Lumen Cytoplasmic Vesicle Lumen Upon Binding To The Slc22a17 (24p3r) Receptor It Is Internalized Releases The Bound Iron In The Acidic Lumen Of Cytoplasmic Vesicles
Alternative CLIA Names	Neutrophil Gelatinase-Associated Lipocalin CLIA kit Ngal CLIA kit 25 Kda Alpha-2-Microglobulin-Related Subunit Of Mmp-9 CLIA kit Lipocalin-2 CLIA kit Oncogene 24p3 CLIA kit Siderocalin CLIA kit P25 CLIA kit LCN2 CLIA kit HNL CLIA kit NGAL CLIA kit
Specificity	This kit recognizes Human NGAL in samples. No significant cross-reactivity or interference between Human NGAL and analogues was observed.
Reproducibility	Both intra-CV and inter-CV are

Information sourced from Uniprot.org

Item Specifications Storage

Micro CLIA Plate (Dismountable)	96T: 8 wells ×12 strips strips	-20℃, 6 months
Reference Standard	96T: 2 vials 48T: 1 vial	-20℃, 6 months
Concentrated Biotinylated Detection Ab (100×)	96T: 1 vial, 120 μL 60 μL	-20℃, 6 months
Concentrated HRP Conjugate (100×)	96T: 1 vial, 120 μL 60 μL	-20℃ (Protect from light), 6 months
Reference Standard & Sample Diluent	1 vial, 20 mL	2-8°C, 6 months
Biotinylated Detection Ab Diluent	1 vial, 14 mL	2-8°C, 6 months
HRP Conjugate Diluent	1 vial, 14 mL	2-8°C, 6 months
Concentrated Wash Buffer (25×)	1 vial, 30 mL	2-8°C, 6 months
Substrate Reagent A	1 vial, 5 mL	2-8℃ (Protect from light)
Substrate Reagent B	1 vial, 5 mL	2-8℃ (Protect from light)
Plate Sealer	5 pieces
Manual	1 copy
Certificate of Analysis	1 copy

Sample Type Range (%) Average Recovery (%)

Serum(n=8)	98-109	104
EDTA plasma(n=8)	97-111	103
Cell culture media(n=8)	93-103	98

Intra-assay Precision Intra-assay Precision Intra-assay Precision Inter-assay Precision Inter-assay Precision Inter-assay Precision

Sample	1.00	2.00	3.00	1.00	2.00	3.00
n	20.00	20.00	20.00	20.00	20.00	20.00
Mean (pg/mL)	100.80	190.47	894.54	92.78	207.90	905.47
Standard deviation	10.15	19.12	67.63	11.66	18.86	81.22
CV (%)	10.07	10.04	7.56	12.57	9.07	8.97

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Human LCN2 (Neutrophil gelatinase-associated lipocalin) CLIA Kit (STJC0000087)