Anti-CD11a/LFA-1A/ITGAL antibody (26-1086) (STJ11102795) STJ11102795 上海玉博生物科技有限公司

Anti-CD11a/LFA-1A/ITGAL antibody (26-1086) (STJ11102795)

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产品名称：Anti-CD11a/LFA-1A/ITGAL antibody (26-1086) (STJ11102795)
产品型号：STJ11102795
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD11a/LFA-1A/ITGAL antibody (26-1086) (STJ11102795)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CD11a/LFA-1A/ITGAL (26-1086) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ITGAL
Gene ID:	3683
Uniprot ID:	ITAL_HUMAN
Immunogen Region:	26-1086
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 26-1086 of human CD11a/LFA-1A/CD11a/LFA-1A/ITGAL (NP_001107852.1).
Immunogen Sequence:	YNLDVRGARSFSPPRAGRHF GYRVLQVGNGVIVGAPGEGN STGSLYQCQSGTGHCLPVTL RGSNYTSKYLGMTLATDPTD GSILFAAVQFSTSYKTEFDF SDYVKRKDPDALLKHVKHML LLTNTFGAINYVATEVFREE LGARPDATKVLIIITDGEAT DSGNIDAAKDIIRYIIGIGK HFQTKESQETLHKFASKPAS EFVKILDTFEKLKDLFTELQ KKIYVIEGTSKQDLTSFNM

Tissue Specificity	Leukocytes.
Post Translational Modifications	In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
Function	Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Protein Name	Integrin Alpha-L Cd11 Antigen-Like Family Member A Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain Lfa-1a Leukocyte Function-Associated Molecule 1 Alpha Chain Cd Antigen Cd11a
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-202733 Reactome: R-HSA-216083 Reactome: R-HSA-6798695 Reactome: R-HSA-8949275
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-Integrin Alpha-L antibody Anti-Cd11 Antigen-Like Family Member A antibody Anti-Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain antibody Anti-Lfa-1a antibody Anti-Leukocyte Function-Associated Molecule 1 Alpha Chain antibody Anti-Cd Antigen Cd11a antibody Anti-ITGAL antibody Anti-CD11A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD11a/LFA-1A/ITGAL antibody (26-1086) (STJ11102795)