Anti-CD11b antibody [EBS-CD-010] (STJ16101084) STJ16101084 上海玉博生物科技有限公司

Anti-CD11b antibody [EBS-CD-010] (STJ16101084)

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产品名称：Anti-CD11b antibody [EBS-CD-010] (STJ16101084)
产品型号：STJ16101084
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD11b antibody [EBS-CD-010] (STJ16101084)

产品描述

Host:	Mouse
Applications:	FC/IF/IHC
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-CD11b is suitable for use in Flow Cytometry, Immunofluorescence and Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	EBS-CD-010
Conjugation:	Unconjugated
Isotype:	IgG1k
Formulation:	PBS with 0.02% Sodium Azide.
Purification:	Affinity purified from tissue culture.
Concentration:	Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range:	Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Immunofluorescence (0, 5-1, 0 µg/ml). Immunohistology (1-2 µg/ml for 30 min at RT; an appropriate antigen retrieval method for staining of formalin-fixed tissues has not been established to date
Storage Instruction:	Store for up to 1 year at 2-8°C upon receipt.

Gene Symbol:	ITGAM
Gene ID:	3684
Uniprot ID:	ITAM_HUMAN
Immunogen:	A BALB/c mouse was immunized with human neutrophils. Fusion partner: P3-X63-Ag8.653.

Tissue Specificity	Predominantly expressed in monocytes and granulocytes. Expressed in neutrophils (at protein level).
Function	Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.
Protein Name	Integrin Alpha-M Cd11 Antigen-Like Family Member B Cr-3 Alpha Chain Cell Surface Glycoprotein Mac-1 Subunit Alpha Leukocyte Adhesion Receptor Mo1 Neutrophil Adherence Receptor Cd Antigen Cd11b
Database Links	Reactome: R-HSA-166016 Reactome: R-HSA-202733 Reactome: R-HSA-216083 Reactome: R-HSA-6785807 Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft
Alternative Antibody Names	Anti-Integrin Alpha-M antibody Anti-Cd11 Antigen-Like Family Member B antibody Anti-Cr-3 Alpha Chain antibody Anti-Cell Surface Glycoprotein Mac-1 Subunit Alpha antibody Anti-Leukocyte Adhesion Receptor Mo1 antibody Anti-Neutrophil Adherence Receptor antibody Anti-Cd Antigen Cd11b antibody Anti-ITGAM antibody Anti-CD11B antibody Anti-CR3A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD11b antibody [EBS-CD-010] (STJ16101084)