Anti-CD123 antibody (26-171aa) [ZM80] (STJ180319) STJ180319 上海玉博生物科技有限公司

Anti-CD123 antibody (26-171aa) [ZM80] (STJ180319)

简单介绍

Anti-CD123 antibody (26-171aa) [ZM80] (STJ180319)

产品描述

Host:	Mouse
Applications:	IHC-P
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-CD123 (26-171aa) is suitable for use in Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	ZM80
Conjugation:	Unconjugated
Isotype:	IgG2b/Kappa
Formulation:	Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification:	Affinity purified
Dilution Range:	1:100‐200
Storage Instruction:	Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.

Gene Symbol:	IL3RA
Gene ID:	3563
Uniprot ID:	IL3RA_HUMAN
Immunogen Region:	26-171aa
Specificity:	Positive control: Lymph node or thymus
Immunogen:	Recombinant fragment of human IL3RA protein (around aa 26-171)

Post Translational Modifications	Ubiquitinated by RNFT2 in response to IL3. Ubiquitination leads ligand-induced degradation by the proteasome.
Function	Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program.
Protein Name	Interleukin-3 Receptor Subunit Alpha Il-3 Receptor Subunit Alpha Il-3r Subunit Alpha Il-3r-Alpha Il-3ra Cd Antigen Cd123
Database Links	Reactome: R-HSA-512988 Reactome: R-HSA-5673001 Reactome: R-HSA-912526
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-Interleukin-3 Receptor Subunit Alpha antibody Anti-Il-3 Receptor Subunit Alpha antibody Anti-Il-3r Subunit Alpha antibody Anti-Il-3r-Alpha antibody Anti-Il-3ra antibody Anti-Cd Antigen Cd123 antibody Anti-IL3RA antibody Anti-IL3R antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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