Anti-BCAR3 antibody (554-825) (STJ11100348) STJ11100348 上海玉博生物科技有限公司

Anti-BCAR3 antibody (554-825) (STJ11100348)

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产品名称：Anti-BCAR3 antibody (554-825) (STJ11100348)
产品型号：STJ11100348
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BCAR3 antibody (554-825) (STJ11100348)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-BCAR3 (554-825) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BCAR3
Gene ID:	8412
Uniprot ID:	BCAR3_HUMAN
Immunogen Region:	554-825
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 554-825 of human BCAR3 (NP_003558.1).
Immunogen Sequence:	QHVLSMDCRVARILGVSEEM RRNMGVSSGLELITLPHGHQ LRLDIIERHNTMAIGIAVDI LGCTGTLEDRAATLSKIIQV AVELKDSMGDLYSFSALMKA LEMPQITRLEKTWTALRHQY TQTAILYEKQLKPFSKLLHE GRESTCVPPNNVSVPLLMPL VTLMERQAVTFEGTDMWEKN DQSCEIMLNHLATARFMAEA ADSYRMNAERILAGFQPDEE MNEICKTEFQMRLLWGSKG

Tissue Specificity	Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue.
Post Translational Modifications	Phosphorylated on tyrosine residues.
Function	Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers. Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis. Promotes insulin-mediated membrane ruffling. In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity. May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction. Regulates EGF-induced DNA synthesis. Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling. Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA. Positively regulates integrin-induced tyrosine phosphorylation of BCAR1. Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS. However, in a contrasting study, lacks GEF activity towards RAP1.
Protein Name	Breast Cancer Anti-Estrogen Resistance Protein 3 Novel Sh2-Containing Protein 2 Sh2 Domain-Containing Protein 3b
Cellular Localisation	Cytoplasm Cell Junction Focal Adhesion Localization To Focal Adhesions Depends On Interaction With Ptpra
Alternative Antibody Names	Anti-Breast Cancer Anti-Estrogen Resistance Protein 3 antibody Anti-Novel Sh2-Containing Protein 2 antibody Anti-Sh2 Domain-Containing Protein 3b antibody Anti-BCAR3 antibody Anti-NSP2 antibody Anti-SH2D3B antibody Anti-UNQ271 antibody Anti-PRO308 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BCAR3 antibody (554-825) (STJ11100348)