Anti-BCAS3 antibody (660-740 aa) (STJ91830) STJ91830 上海玉博生物科技有限公司

Anti-BCAS3 antibody (660-740 aa) (STJ91830)

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产品名称：Anti-BCAS3 antibody (660-740 aa) (STJ91830)
产品型号：STJ91830
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BCAS3 antibody (660-740 aa) (STJ91830)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-BCAS3 microtubule associated cell migration factor (660-740 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 ELISA 1:5000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BCAS3
Gene ID:	54828
Uniprot ID:	BCAS3_HUMAN
Immunogen Region:	660-740 aa
Specificity:	BCAS3 Polyclonal Antibody detects endogenous levels of BCAS3 protein.
Immunogen:	Synthesized peptide derived from BCAS3 at the amino acid range 660-740

Function	Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation. Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy. Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures.
Protein Name	Bcas3 Microtubule Associated Cell Migration Factor Breast Carcinoma-Amplified Sequence 3 Gaob1
Cellular Localisation	Nucleus Cytoplasm Cytoskeleton Preautophagosomal Structure Localizes In The Cytoplasm In Stationary Cells Translocates From The Cytoplasm To The Leading Edge In Motile Cells Colocalizes With Microtubules And Intermediate Filaments In Both Stationary And Motile Cells Associates With Chromatin Recruited To Estrogen Receptor-Induced Promoters In A Pelp1-Dependent Manner The Bcas3:Phaf1 Complex Is Recruited To The Preautophagosomal Structures Adjacent To The Damaged Mitochondria Upon Mitophagy In A Prkn-Pink1 Dependent Manner
Alternative Antibody Names	Anti-Bcas3 Microtubule Associated Cell Migration Factor antibody Anti-Breast Carcinoma-Amplified Sequence 3 antibody Anti-Gaob1 antibody Anti-BCAS3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BCAS3 antibody (660-740 aa) (STJ91830)