Anti-BCCIP antibody (60-140 aa) (STJ96059) STJ96059 上海玉博生物科技有限公司

Anti-BCCIP antibody (60-140 aa) (STJ96059)

简单介绍

Anti-BCCIP antibody (60-140 aa) (STJ96059)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-BRCA2 and CDKN1A-interacting protein (60-140 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 ELISA 1:5000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BCCIP
Gene ID:	56647
Uniprot ID:	BCCIP_HUMAN
Immunogen Region:	60-140 aa
Specificity:	TOK-1 Polyclonal Antibody detects endogenous levels of TOK-1 protein.
Immunogen:	Synthesized peptide derived from TOK-1 at the amino acid range 60-140

Function	During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
Protein Name	Brca2 And Cdkn1a-Interacting Protein P21- And Cdk-Associated Protein 1 Protein Tok-1
Cellular Localisation	Nucleus Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Centriole Spindle Pole Colocalizes With Brca2 In Discrete Nuclear Foci In Interphase Preferential Localizes To The Mother Centriole Recruited To The Spindle Pole Matrix And Centrosome By Microtubules And Dynein/Dynactin Activity Isoform 1: Cytoplasm Isoform 1/Beta Tends To Be Less Abundant At And Less Strongly Associated With Centrosomes Than Isoform 2/Alpha Isoform 2: Cytoplasm Isoform 2/Alpha Tends To Be More Abundant At And More Strongly Associated With Centrosomes Than Isoform 1/Beta
Alternative Antibody Names	Anti-Brca2 And Cdkn1a-Interacting Protein antibody Anti-P21- And Cdk-Associated Protein 1 antibody Anti-Protein Tok-1 antibody Anti-BCCIP antibody Anti-TOK1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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