Human LDLR (Low-density lipoprotein receptor) CLIA Kit (STJC0000552) STJC0000552 上海玉博生物科技有限公司

Human LDLR (Low-density lipoprotein receptor) CLIA Kit (STJC0000552)

简单介绍

Human LDLR (Low-density lipoprotein receptor) CLIA Kit (STJC0000552)

产品描述

Applications:	CLIA
Reactivity:	Human
Note:	FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Sensitivity:	37.5pg/mL
Detection Limit:	62.5~4000pg/mL
Short Description:	This human LDLR kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.

Storage Instruction:	If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
Assay Time:	3.5h
Detection:	Chemiluminescence

Gene Symbol:	LDLR
Gene ID:	3949
Uniprot ID:	LDLR_HUMAN
Specificity:	This kit recognizes Human LDLR in samples. No significant cross-reactivity or interference between Human LDLR and analogues was observed.
Sample Type:	Serum, plasma and other biological fluids

Post Translational Modifications	N- and O-glycosylated. Ubiquitinated by MYLIP leading to degradation.
Function	Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
Protein Name	Low-Density Lipoprotein Receptor Ldl Receptor
Database Links	Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-8964026 Reactome: R-HSA-8964038 Reactome: R-HSA-975634
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Membrane Clathrin-Coated Pit Golgi Apparatus Early Endosome Late Endosome Lysosome Rapidly Endocytosed Upon Ligand Binding
Alternative CLIA Names	Low-Density Lipoprotein Receptor CLIA kit Ldl Receptor CLIA kit LDLR CLIA kit
Specificity	This kit recognizes Human LDLR in samples. No significant cross-reactivity or interference between Human LDLR and analogues was observed.
Reproducibility	Both intra-CV and inter-CV are

Information sourced from Uniprot.org

Item Specifications Storage

Micro CLIA Plate (Dismountable)	96T: 8 wells ×12 strips strips	-20℃, 6 months
Reference Standard	96T: 2 vials 48T: 1 vial	-20℃, 6 months
Concentrated Biotinylated Detection Ab (100×)	96T: 1 vial, 120 μL 60 μL	-20℃, 6 months
Concentrated HRP Conjugate (100×)	96T: 1 vial, 120 μL 60 μL	-20℃ (Protect from light), 6 months
Reference Standard & Sample Diluent	1 vial, 20 mL	2-8°C, 6 months
Biotinylated Detection Ab Diluent	1 vial, 14 mL	2-8°C, 6 months
HRP Conjugate Diluent	1 vial, 14 mL	2-8°C, 6 months
Concentrated Wash Buffer (25×)	1 vial, 30 mL	2-8°C, 6 months
Substrate Reagent A	1 vial, 5 mL	2-8℃ (Protect from light)
Substrate Reagent B	1 vial, 5 mL	2-8℃ (Protect from light)
Plate Sealer	5 pieces
Manual	1 copy
Certificate of Analysis	1 copy

Sample Type Range (%) Average Recovery (%)

Intra-assay Precision Intra-assay Precision Intra-assay Precision Inter-assay Precision Inter-assay Precision Inter-assay Precision

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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