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Human LEP (LEP) Sandwich ELISA Kit (STJE0000023)
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Human LEP (LEP) Sandwich ELISA Kit (STJE0000023)
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Human LEP (LEP) Sandwich ELISA Kit (STJE0000023)
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产品名称:
Human LEP (LEP) Sandwich ELISA Kit (STJE0000023)
产品型号:
STJE0000023-96
产品展商:
ST john's laboratory
产品文档:
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简单介绍
Human LEP (LEP) Sandwich ELISA Kit (STJE0000023)
产品描述
Applications:
ELISA
Reactivity:
Human
Note:
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:
15.6 pg/mL
Detection Limit:
312-2000 pg/ml
Short Description:
This LEP Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Conjugation:
Biotin
Storage Instruction:
Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time:
4 hours
Detection:
Colorimetric
Gene Symbol:
LEP
Gene ID:
3952
Uniprot ID:
LEP_HUMAN
Sample Type:
serum, plasma and cell culture supernates
Tissue Specificity
Adipose tissue is the main source of leptin. It is also produced by other peripheral tissues such as the skeletal muscle. Expressed by intercalated and striated tracts of submandibular and parotid salivary gland intralobular ducts. Detected by fundic epithelium of the gastric mucosa. Secreted into blood and gastric juice.
Post Translational Modifications
Function
Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation.
Protein Name
Leptin
Obese Protein
Obesity Factor
Database Links
Reactome: R-HSA-2586552
Reactome: R-HSA-381340
Reactome: R-HSA-381771
Reactome: R-HSA-422085
Cellular Localisation
Secreted
Alternative ELISA Names
Leptin ELISA kit
Obese Protein ELISA kit
Obesity Factor ELISA kit
LEP ELISA kit
OB ELISA kit
OBS ELISA kit
output
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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