Anti-CD14 antibody (250-350) [S9MR] (STJ11101549) STJ11101549 上海玉博生物科技有限公司

Anti-CD14 antibody (250-350) [S9MR] (STJ11101549)

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产品名称：Anti-CD14 antibody (250-350) [S9MR] (STJ11101549)
产品型号：STJ11101549
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD14 antibody (250-350) [S9MR] (STJ11101549)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/FC
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-CD14 (250-350) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and Flow Cytometry research applications.

Clonality:	Monoclonal
Clone ID:	S9MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200 FC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CD14
Gene ID:	929
Uniprot ID:	CD14_HUMAN
Immunogen Region:	250-350
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CD14 (P08571).
Immunogen Sequence:	QPHSLDLSHNSLRATVNPSA PRCMWSSALNSLNLSFAGLE QVPKGLPAKLRVLDLSCNRL NRAPQPDELPEVDNLTLDGN PFLVPGTALPHEGSMNSGVV P

Tissue Specificity	Detected on macrophages (at protein level). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes.also expressed by most tissue macrophages.
Post Translational Modifications	N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
Function	Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
Protein Name	Monocyte Differentiation Antigen Cd14 Myeloid Cell-Specific Leucine-Rich Glycoprotein Cd Antigen Cd14 Cleaved Into - Monocyte Differentiation Antigen Cd14 - Urinary Form - Monocyte Differentiation Antigen Cd14 - Membrane-Bound Form
Database Links	Reactome: R-HSA-1236974 Reactome: R-HSA-140534 Reactome: R-HSA-166016 Reactome: R-HSA-166020 Reactome: R-HSA-166058 Reactome: R-HSA-166166 Reactome: R-HSA-168179 Reactome: R-HSA-168188 Reactome: R-HSA-2562578 Reactome: R-HSA-5602498 Reactome: R-HSA-5603041 Reactome: R-HSA-5686938 Reactome: R-HSA-6798695 Reactome: R-HSA-936964 Reactome: R-HSA-937041 Reactome: R-HSA-937072 Reactome: R-HSA-975163
Cellular Localisation	Cell Membrane Lipid-Anchor Gpi-Anchor Secreted Membrane Raft Golgi Apparatus Secreted Forms May Arise By Cleavage Of The Gpi Anchor
Alternative Antibody Names	Anti-Monocyte Differentiation Antigen Cd14 antibody Anti-Myeloid Cell-Specific Leucine-Rich Glycoprotein antibody Anti-Cd Antigen Cd14 Cleaved Into - Monocyte Differentiation Antigen Cd14 - Urinary Form - Monocyte Differentiation Antigen Cd14 - Membrane-Bound Form antibody Anti-CD14 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD14 antibody (250-350) [S9MR] (STJ11101549)