Anti-BCL2 antibody (N-Term) (STJ70579) STJ70579-100 上海玉博生物科技有限公司

Anti-BCL2 antibody (N-Term) (STJ70579)

如果您对该产品感兴趣的话，可以
产品名称：Anti-BCL2 antibody (N-Term) (STJ70579)
产品型号：STJ70579-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BCL2 antibody (N-Term) (STJ70579)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB
Reactivity:	Human/Mouse/Rat/Dog
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BCL2 (N-Term) is suitable for use in ELISA and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-0.1-0.3µg/ml ELISA-antibody detection limit dilution 1:64000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	BCL2
Gene ID:	596
Uniprot ID:	BCL2_HUMAN
Immunogen Region:	N-Term
Accession Number:	NP_000624.2; NP_000648.2
Specificity:	This antibody is expected to recognise both reported isoforms (NP_000624; NP_000648)
Immunogen Sequence:	AGRTGYDNREIVMKYC

Post Translational Modifications	Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates starvation-induced autophag. Dephosphorylated by protein phosphatase 2A (PP2A). Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further caspase activity. Monoubiquitinated by PRKN, leading to an increase in its stability. Ubiquitinated by SCF(FBXO10), leading to its degradation by the proteasome. Ubiquitinated by XIAP, leading to its degradation by the proteasome.
Function	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function. May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.
Protein Name	Apoptosis Regulator Bcl-2
Database Links	Reactome: R-HSA-111447 Reactome: R-HSA-111453 Reactome: R-HSA-6785807 Reactome: R-HSA-844455 Reactome: R-HSA-9018519 Reactome: R-HSA-9634638
Cellular Localisation	Mitochondrion Outer Membrane Single-Pass Membrane Protein Nucleus Membrane Endoplasmic Reticulum Membrane Cytoplasm
Alternative Antibody Names	Anti-Apoptosis Regulator Bcl-2 antibody Anti-BCL2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-BCL2 antibody (N-Term) (STJ70579)