Anti-CD160 antibody (1-181) (STJ110488) STJ110488 上海玉博生物科技有限公司

Anti-CD160 antibody (1-181) (STJ110488)

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产品名称：Anti-CD160 antibody (1-181) (STJ110488)
产品型号：STJ110488
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD160 antibody (1-181) (STJ110488)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CD160 (1-181) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CD160
Gene ID:	11126
Uniprot ID:	BY55_HUMAN
Immunogen Region:	1-181
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human CD160 (NP_008984.1).
Immunogen Sequence:	MLLEPGRGCCALAILLAIVD IQSGGCINITSSASQEGTRL NLICTVWHKKEEAEGFVVFL CKDRSGDCSPETSLKQLRLK RDPGIDGVGEISSQLMFTIS QVTPLHSGTYQCCARSQKSG IRLQGHFFSILFTETGNYTV TGLKQRQHLEFSHNEGTLSS GFLQEKVWVMLVTSLVALQA L

Tissue Specificity	Expression is restricted to functional NK and cytotoxic T lymphocytes. Expressed in viral-specific effector memory and terminally differentiated effector memory CD8+ T cells. Expressed in memory and activated CD4+ T cell subsets (at protein level). Expressed at high levels in intraepithelial lymphocytes (at protein level). Expressed in both alpha-beta and gamma-delta CD8+ T cell subsets (at protein level). Expressed in umbilical vein endothelial cells (at protein level). Expressed in monocytes and at lower levels in B cells. Isoform 3: Expressed exclusively in activated NK cells (at protein level).
Function	CD160 antigen: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells. Receptor for both classical and non-classical MHC class I molecules. In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response. On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells. Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion. On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites. Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response. On activated CD4+ T cells, interacts with TNFRSF14 and down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and pro-inflammatory cytokines. CD160 antigen, soluble form: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.
Protein Name	Cd160 Antigen Natural Killer Cell Receptor By55 Cd Antigen Cd160 Cleaved Into - Cd160 Antigen - Soluble Form
Database Links	Reactome: R-HSA-198933
Cellular Localisation	Cd160 Antigen: Cell Membrane Lipid-Anchor Gpi-Anchor Cd160 Antigen Soluble Form: Secreted Released From The Cell Membrane By Gpi Cleavage
Alternative Antibody Names	Anti-Cd160 Antigen antibody Anti-Natural Killer Cell Receptor By55 antibody Anti-Cd Antigen Cd160 Cleaved Into - Cd160 Antigen - Soluble Form antibody Anti-CD160 antibody Anti-BY55 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD160 antibody (1-181) (STJ110488)