Anti-CD163 antibody (1-100 aa) [ABT-CD163] (STJ196804) STJ196804 上海玉博生物科技有限公司

Anti-CD163 antibody (1-100 aa) [ABT-CD163] (STJ196804)

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产品名称：Anti-CD163 antibody (1-100 aa) [ABT-CD163] (STJ196804)
产品型号：STJ196804
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD163 antibody (1-100 aa) [ABT-CD163] (STJ196804)

产品描述

Host:	Mouse
Applications:	IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Scavenger receptor cysteine-rich type 1 protein M130 (1-100 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Monoclonal
Clone ID:	ABT-CD163
Conjugation:	Unconjugated
Isotype:	IgG1k
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Dilution Range:	IHC-P 1:100-500 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CD163
Gene ID:	9332
Uniprot ID:	C163A_HUMAN
Immunogen Region:	1-100 aa
Specificity:	This antibody detects endogenous levels of human CD163. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section
Immunogen:	Synthesized peptide derived from the human CD163 at the amino acid range 1-100

Post Translational Modifications	A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. Phosphorylated.
Function	Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Protein Name	Scavenger Receptor Cysteine-Rich Type 1 Protein M130 Hemoglobin Scavenger Receptor Cd Antigen Cd163 Cleaved Into - Soluble Cd163 Scd163
Database Links	Reactome: R-HSA-2168880 Reactome: R-HSA-9662834
Cellular Localisation	Soluble Cd163: Secreted Cell Membrane Single-Pass Type I Membrane Protein Isoform 1 And Isoform 2 Show A Lower Surface Expression When Expressed In Cells
Alternative Antibody Names	Anti-Scavenger Receptor Cysteine-Rich Type 1 Protein M130 antibody Anti-Hemoglobin Scavenger Receptor antibody Anti-Cd Antigen Cd163 Cleaved Into - Soluble Cd163 antibody Anti-Scd163 antibody Anti-CD163 antibody Anti-M130 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD163 antibody (1-100 aa) [ABT-CD163] (STJ196804)