Anti-CD163 antibody (750-1050) (STJ110681) STJ110681 上海玉博生物科技有限公司

Anti-CD163 antibody (750-1050) (STJ110681)

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产品名称：Anti-CD163 antibody (750-1050) (STJ110681)
产品型号：STJ110681
产品展商：ST john's laboratory
产品文档：无相关文档

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Anti-CD163 antibody (750-1050) (STJ110681)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CD163 (750-1050) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CD163
Gene ID:	9332
Uniprot ID:	C163A_HUMAN
Immunogen Region:	750-1050
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 750-1050 of human CD163 (NP_004235.4?).
Immunogen Sequence:	LSDAHVVCRQLGCGEAINAT GSAHFGEGTGPIWLDEMKCN GKESRIWQCHSHGWGQQNCR HKEDAGVICSEFMSLRLTSE ASREACAGRLEVFYNGAWGT VGKSSMSETTVGVVCRQLGC ADKGKINPASLDKAMSIPMW VDNVQCPKGPDTLWQCPSSP WEKRLASPSEETWITCDNKI RLQEGPTSCSGRVEIWHGGS WGTVCDDSWDLDDAQVVCQQ LGCGPALKAFKEAEFGQGT

Tissue Specificity	Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.
Post Translational Modifications	A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. Phosphorylated.
Function	Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Protein Name	Scavenger Receptor Cysteine-Rich Type 1 Protein M130 Hemoglobin Scavenger Receptor Cd Antigen Cd163 Cleaved Into - Soluble Cd163 Scd163
Database Links	Reactome: R-HSA-2168880 Reactome: R-HSA-9662834
Cellular Localisation	Soluble Cd163: Secreted Cell Membrane Single-Pass Type I Membrane Protein Isoform 1 And Isoform 2 Show A Lower Surface Expression When Expressed In Cells
Alternative Antibody Names	Anti-Scavenger Receptor Cysteine-Rich Type 1 Protein M130 antibody Anti-Hemoglobin Scavenger Receptor antibody Anti-Cd Antigen Cd163 Cleaved Into - Soluble Cd163 antibody Anti-Scd163 antibody Anti-CD163 antibody Anti-M130 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD163 antibody (750-1050) (STJ110681)