Anti-BCL2L10 antibody (70-150 aa) (STJ191659) STJ191659 上海玉博生物科技有限公司

Anti-BCL2L10 antibody (70-150 aa) (STJ191659)

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产品名称：Anti-BCL2L10 antibody (70-150 aa) (STJ191659)
产品型号：STJ191659
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BCL2L10 antibody (70-150 aa) (STJ191659)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Bcl-2-like protein 10 (70-150 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BCL2L10
Gene ID:	10017
Uniprot ID:	B2L10_HUMAN
Immunogen Region:	70-150 aa
Specificity:	B2L10 Polyclonal Antibody detects endogenous levels of protein.
Immunogen:	Synthesized peptide derived from the human protein at the amino acid range 70-150

Post Translational Modifications	Monoubiquitinated by UBQLN1.results in stabilization of BCL2L10 protein abundance and in relocalization from mitochondria to cytoplasm.
Function	Promotes cell survival by suppressing apoptosis induced by BAX but not BAK. Increases binding of AHCYL1/IRBIT to ITPR1. Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions. Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis. Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2.
Protein Name	Bcl-2-Like Protein 10 Bcl2-L-10 Anti-Apoptotic Protein Boo Anti-Apoptotic Protein Nrh Apoptosis Regulator Bcl-B
Cellular Localisation	Mitochondrion Nucleus Membrane Endoplasmic Reticulum Cytoplasm Cytoskeleton Spindle Localizes To Mitochondria-Associated Endoplasmic Reticulum Membranes (Mams) Localization To Mams Is Greatly Reduced Under Apoptotic Stress Conditions
Alternative Antibody Names	Anti-Bcl-2-Like Protein 10 antibody Anti-Bcl2-L-10 antibody Anti-Anti-Apoptotic Protein Boo antibody Anti-Anti-Apoptotic Protein Nrh antibody Anti-Apoptosis Regulator Bcl-B antibody Anti-BCL2L10 antibody Anti-BCL-B antibody Anti-BCLB antibody Anti-BOO antibody Anti-DIVA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BCL2L10 antibody (70-150 aa) (STJ191659)